IL-10: An “Immunologic Scalpel” for Atherosclerosis?
نویسندگان
چکیده
منابع مشابه
IL-10: An "immunologic scalpel" for atherosclerosis?
Mononuclear leukocyte–mediated inflammation is a central feature of atherosclerosis. Using measures that diminish lesion monocyte recruitment and macrophage-mediated inflammation, investigators have shown these specific events to be essential to the development and progression of atherosclerotic lesions. Lesion T lymphocytes have an activated phenotype and colocalize with lesion macrophages, pa...
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Cardiovascular diseases, including coronary artery disease (CAD), ischemic gangrene, abdominal aortic aneurysms, and many cases of heart failure and stroke currently account for the most number of deaths in the Western world (Hansson et al., 2006). The root cause of these diseases is atherosclerosis, which is widely accepted these days to be a chronic inflammatory disease in addition to the mor...
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The aim of the present study was to clarify if old N-MRI rat, a strain which is easily available in Iran and cheap to maintain, is a suitable alternative to those previously reported. In this model, we compared three quantifiable parameters between old and young rats: biochemically, involving measurement of differences in the lipid profile. Histologically, the differences of the thickness of th...
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T cell cytokines are known to play a major role in determining protection and pathology in infectious disease. It has recently become clear that IL-12 is a key inducer of the type 1 T cell cytokine pattern characterized by production of IFN-gamma. Conversely, IL-10 down-regulates IL-12 production and type 1 cytokine responses. We have investigated whether IL-12 and IL-10 might be involved in a ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 1999
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.19.12.2823